Intestinal beta-carotene absorption and cleavage in men : response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene
article
Postprandial response curves of β-carotene and retinyl esters in a triglyceride-rich lipoprotein (TRL) fraction were evaluated as a potential measure of β-carotene uptake and cleavage. β-Carotene, retinyl ester, and triglyceride concentrations in the TRI, fraction (density < 1.006 kg/L) and plasma were measured in 10 men for 8 or 16 h after an oral dose of 15 mg β- carotene. The β-carotene response, unlike the triglyceride and retinyl ester response, can be evaluated in the TRL fraction but not in plasma. Intraindividual variations in the triglyceride-adjusted response of β- carotene and retinyl palmitate in TRL fractions were 23% and 20% and interindividual variations were 42% and 36%, respectively. A low β-carotene response was associated with a high ratio between retinyl palmitate and β- carotene responses (r = -0.56, P = 0.013). In conclusion, the measurement of β-carotene and retinyl esters in the TRL fraction after a dose of β- carotene with a vitamin A-free meal may be an appropriate method to study β- carotene uptake and cleavage
Topics
β-caroteneChylomicronsInterindividual variationIntraindividual variationPlasmaResponseRetinyl estersSecond mealSingle doseTriglyceridesAlpha tocopherolArachidic acidBeta caroteneLipoproteinRetinolRetinol esterRetinol palmitateRetinol stearateSugarTriacylglycerolYoghurtAdultBlood levelClinical articleClinical trialControlled clinical trialControlled studyDietary intakeDrug degradationHumanHuman tissueIntestine absorptionMaleOral drug administrationTest mealAdministration, OralAdultBeta CaroteneCarotenoidsHumansIntestinal AbsorptionIntestinesLipoproteinsMaleTriglyceridesVitamin A
TNO Identifier
82574
Source
American Journal of Clinical Nutrition, 62, pp. 110-116.
Pages
110-116
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